MicroRNAs and Autoimmune-Mediated Eye Diseases

Frontiers in Cell and Developmental Biology

Binyun Ma¹  Ruihua Wei²  Yankai Wei²  Chao Yang²  Lu Zhao²  Xiaorong Li²  Hong Nian²  Na Li² 

[1] Department of Medicine/Hematology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, United States;Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin International Joint Research and Development Centre of Ophthalmology and Vision Science, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China;

关键词: miRNAs;    autoimmune uveitis;    Grave’s ophthalmopathy;    Sjögren’s syndrome dry eye;    biomarkers;    therapeutic targets;   

DOI  :  10.3389/fcell.2020.00818

来源: DOAJ

【 摘 要 】

MicroRNAs (miRNAs) are evolutionarily conserved short non-coding RNAs that act at post-transcriptional regulation of gene expression by destroying target messenger RNA or inhibiting its translation. Recently, miRNAs have been identified as important regulators in autoimmunity. Aberrant expression and function of miRNAs can lead to dysfunction of immune system and mediate autoimmune disorders. Here, we summarize the roles of miRNAs that have been implicated in three representative ocular autoimmune disorders, including autoimmune uveitis, Grave’s ophthalmopathy, and Sjögren’s syndrome dry eye, and discuss the potential of miRNAs as biomarkers and therapeutic targets for the diagnosis and treatment of these diseases.

【 授权许可】

Unknown