Novelty search employed into the development of cancer treatment simulations

Informatics in Medicine Unlocked

Larry Bull¹  Andrew Adamatzky²  Michail-Antisthenis Tsompanas³  Igor Balaz³ 

[1] Corresponding author.;Department of Computer Science and Creative Technologies, University of the West of England, Bristol, BS16 1QY, UK;Unconventional Computing Laboratory, University of the West of England, Bristol, BS16 1QY, UK;

关键词: Novelty search;    Cancer treatment;    Evolutionary algorithm;    PhysiCell;    Simulator;    Optimization;   

DOI  :  

来源: DOAJ

【 摘 要 】

Conventional optimization methodologies may be hindered when the automated search is stuck into local optima because of a deceptive objective function landscape. Consequently, open ended search methodologies, such as novelty search, have been proposed to tackle this issue. Overlooking the objective, while putting pressure into discovering novel solutions may lead to better solutions in practical problems. Novelty search was employed here to optimize the simulated design of a targeted drug delivery system for tumor treatment under the PhysiCell simulator. A hybrid objective equation was used containing both the actual objective of an effective tumor treatment and the novelty measure of the possible solutions. Different weights of the two components of the hybrid equation were investigated to unveil the significance of each one.

【 授权许可】

Unknown