Unusual onset of thyroid associated orbitopathy during pregnancy: case report and review of literature

BMC Endocrine Disorders

Geza Toth¹  Attila Jakab²  Tamas Deli²  Janos K. Aranyosi³  Bernadett Ujhelyi³  Mariann Fodor³  Annamaria Erdei⁴  Endre V. Nagy⁴ 

[1] Department of Internal Medicine, Szent Lázár Hospital;Department of Obstetrics and Gynecology, Faculty of Medicine, University of Debrecen;Department of Ophthalmology, Faculty of Medicine, University of Debrecen;Division of Endocrinology Department of Internal Medicine, Faculty of Medicine, University of Debrecen;

关键词: TAO;    Graves’ disease;    Pregnancy;    Orbitopathy;    Smoking;    Case report;   

DOI  :  10.1186/s12902-020-00663-9

来源: DOAJ

【 摘 要 】

Abstract Background Thyroid associated orbitopathy (TAO) is the most common extrathyroidal complication of Graves’ disease. The disease course ranges from mild, where symptomatic therapy is sufficient, to severe, where high dose steroid administration or orbital decompression surgery is required. Women of their reproductive age are more likely to be affected. Although pregnancy is a state of enhanced immune tolerance, TAO may develop or worsen in 0.2–0.4% of pregnant women. Case presentation We present the case of a 19-year-old woman who has developed hyperthyroidism and progressive TAO during the second trimester of her third pregnancy, which has improved postpartum. The possible mechanisms and the importance of follow up in pregnancy is discussed. Conclusions Expectant mothers with Graves’ disease require follow up of eye signs throughout pregnancy, preferably in the setting of a thyroid-eye clinic.

【 授权许可】

Unknown