Long Non-Coding RNAs in Pancreatic Cancer: Biologic Functions, Mechanisms, and Clinical Significance

Cancers

Xiaolin Hu¹  Qinglei Hang²  Sicong Hou³  Jiajia Li³  Ziping Ye⁴  Wujun Wang⁵ 

[1] Department of Clinical Medicine, Medical College, Yangzhou University, Yangzhou 225001, China;Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;Department of Gastroenterology, The Affiliated Hospital of Yangzhou University, Yangzhou 225009, China;Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China;Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing 210023, China;

关键词: LncRNAs;    pancreatic cancer;    biomarker;    cancer diagnosis and therapy;   

DOI  :  10.3390/cancers14092115

来源: DOAJ

【 摘 要 】

Despite tremendous efforts devoted to research in pancreatic cancer (PC), the mechanism underlying the tumorigenesis and progression of PC is still not completely clear. Additionally, ideal biomarkers and satisfactory therapeutic strategies for clinical application in PC are still lacking. Accumulating evidence suggests that long non-coding RNAs (lncRNAs) might participate in the pathogenesis of diverse cancers, including PC. The abnormal expression of lncRNAs in PC is considered a vital factor during tumorigenesis that affects tumor cell proliferation, migration, invasion, apoptosis, angiogenesis, and drug resistance. With this review of relevant articles published in recent years, we aimed to summarize the biogenesis mechanism, classifications, and modes of action of lncRNAs and to review the functions and mechanisms of lncRNAs in PC. Additionally, the clinical significance of lncRNAs in PC was discussed. Finally, we pointed out the questions remaining from recent studies and anticipated that further investigations would address these gaps in knowledge in this field.

【 授权许可】

Unknown