Virus-like Particles as Preventive and Therapeutic Cancer Vaccines

Vaccines

Maria Tagliamonte¹  Luigi Buonaguro¹  Anna Lucia Tornesello²  Maria Lina Tornesello²  Franco M. Buonaguro² 

[1] Innovative Immunological Models, Istituto Nazionale Tumori IRCCS “Fondazione G. Pascale”, via Mariano Semmola, 80131 Napoli, Italy;Molecular Biology and Viral Oncology Unit, Istituto Nazionale Tumori IRCCS “Fondazione G. Pascale”, via Mariano Semmola, 80131 Napoli, Italy;

关键词: virus-like particles;    VLPs;    cancer vaccine;    antigen delivery;    human papillomavirus;    HPV;   

DOI  :  10.3390/vaccines10020227

来源: DOAJ

【 摘 要 】

Virus-like particles (VLPs) are self-assembled viral protein complexes that mimic the native virus structure without being infectious. VLPs, similarly to wild type viruses, are able to efficiently target and activate dendritic cells (DCs) triggering the B and T cell immunities. Therefore, VLPs hold great promise for the development of effective and affordable vaccines in infectious diseases and cancers. Vaccine formulations based on VLPs, compared to other nanoparticles, have the advantage of incorporating multiple antigens derived from different proteins. Moreover, such antigens can be functionalized by chemical modifications without affecting the structural conformation or the antigenicity. This review summarizes the current status of preventive and therapeutic VLP-based vaccines developed against human oncoviruses as well as cancers.

【 授权许可】

Unknown