Activation of carbonic anhydrase isoforms involved in modulation of emotional memory and cognitive disorders with histamine agonists, antagonists and derivatives

Journal of Enzyme Inhibition and Medicinal Chemistry

Maria Beatrice Passani¹  Gustavo Provensi²  Alessio Nocentini²  Patrizio Blandina²  Claudiu T. Supuran² 

[1] Department of Health Science, University of Florence, Section of Clinical Pharmacology and Oncology;Department of NEUROFARBA, University of Florence, Section of Pharmacology and Toxicology;

关键词: carbonic anhydrase;    activators;    cognition-related disorders;    histamine receptors;    agonists/antagonists;   

DOI  :  10.1080/14756366.2021.1891051

来源: DOAJ

【 摘 要 】

Carbonic anhydrases (CAs, EC 4.2.1.1) activators were shown to be involved in memory enhancement and learning in animal models of cognition. Here we investigated the CA activating effects of a large series of histamine based compounds, including histamine receptors (H1R – H4R) agonists, antagonists and other derivatives of this autacoid. CA activators may be thus useful for improving cognition as well as in diverse therapeutic areas (phobias, obsessive-compulsive disorder, generalised anxiety, post-traumatic stress disorders), for which activation of this enzyme was recently shown to be involved.

【 授权许可】

Unknown