Neonatal thrombosis: risk factors and principles of prophylaxis

Акушерство, гинекология и репродукция

L. L. Pankratyeva¹  G. C. Di Renzo²  V. I. Tsibizova³  D. V. Blinov⁴  A. V. Vorobev⁴  N. A. Makatsariya⁴  V. O. Bitsadze⁴  J. Kh. Khizroeva⁴  S. A. Potapkina⁴  G. Rizzo⁴ 

[1] Center for Prenatal and Reproductive Medicine, University of Perugia;University of Rome Tor Vergata;Institute for Preventive and Social Medicine;Sechenov University;

关键词: neonatal thrombosis;    risk factors;    central venous catheter;    von willebrand factor;    vwf;    adamts-13;    thrombophilia;    antiphospholipid antibody circulation;    thrombotic microangiopathy;    neonatal thrombosis prophylaxis;   

DOI  :  10.17749/2313-7347/ob.gyn.rep.2021.233

来源: DOAJ

【 摘 要 】

Data analysis on the pathogenesis and risk factors of neonatal thrombosis was carried out. The main risk factor of any neonatal thrombosis is central catheter installment, but other maternal, fetal and neonatal factors should be taken into consideration. We discuss the epidemiology of neonatal thrombosis and the main features of the hemostasis system in newborns, the most significant risk factors, including genetic and acquired thrombophilia. We consider the von Willebrand factor activity and ADAMTS-13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) level in the development of neonatal thrombotic microangiopathy. Finally, we discuss the basic principles of prevented neonatal thrombosis by using low molecular weight heparins.

【 授权许可】

Unknown