Ocular development in children with unilateral congenital cataract and persistent fetal vasculature

International Journal of Ophthalmology

Hui Chen¹  Jing-Hui Wang²  Wei-Rong Chen³  Jing-Jing Chen³  Wan Chen³  Zhuo-Ling Lin³  Duo-Ru Lin³  Qi-Wei Wang³  Xiao-Shan Lin³  Hao-Tian Lin³  Shu-Yi Zhang⁴ 

[1] [e-mail];[e-mail];State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, Guangdong Province, China;Wei-Rong Chen, Hao-Tian Lin, and Duo-Ru Lin. Zhongshan Ophthalmic Center, Xian Lie South Road 54, Guangzhou 510060, Guangdong Province, China. [e-mail];

关键词: ocular development;    congenital cataract;    persistent fetal vasculature;    axial length;    keratometry;   

DOI  :  10.18240/ijo.2022.03.09

来源: DOAJ

【 摘 要 】

AIM: To investigate the ocular development of patients who had unilateral congenital cataract (CC) combined with persistent fetal vasculature (PFV). METHODS: This cross-sectional, observational study included patients who had unilateral CC and PFV and those with isolated unilateral CC. Axial length (AL), keratometry, anterior chamber depth (ACD), lens thickness, and vitreous length were obtained. The ocular biometric parameters of the affected eyes of patients with CC and PFV were compared with the fellow eyes and with the affected eyes of patients with isolated CC. RESULTS: A total of 110 patients were included and divided into 4 groups: group 1 (18 patients with CC and PFV, <24mo), group 2 (22 patients with CC and PFV, ≥24mo), group 3 (35 patients with CC, <24mo), and group 4 (35 patients with CC, ≥24mo). The ALs of the affected eyes were shorter than those of the fellow eyes in group 1 (20.02±1.06 vs 20.66±0.63 mm, P=0.025). While the ALs of the affected eyes were longer than those of the fellow eyes in group 2 (23.18±2.00 vs 22.31±1.06 mm, P=0.044) and group 4 (22.64±1.80 vs 22.02±1.01 mm, P=0.033). The keratometries of the affected eyes were steeper than those of the fellow eyes in group 2 (44.78±1.66 vs 43.83±1.38 D, P=0.041) and group 4 (43.76±1.91 vs 43.34±1.46 D, P=0.043). No difference of ACDs between two eyes was found in all groups (all P>0.05). CONCLUSION: Compared with the fellow eyes, the ALs of the eyes with unilateral CC and PFV are shorter in patients younger than 24mo and longer in those older than 24mo; the keratometries of the eyes with unilateral CC and PFV are steeper in patients older than 24mo and similar with those younger than 24mo. These findings provide further understanding of ocular development in patients with both CC and PFV.

【 授权许可】

Unknown