A novel 4-aminoantipyrine-Pd(II) complex catalyzes Suzuki–Miyaura cross-coupling reactions of aryl halides

Beilstein Journal of Organic Chemistry

Darío Mendoza-Rayo¹  Luis Chacón-García¹  José A. Rincón-Medina²  Claudia A. Contreras-Celedón² 

[1] fax: [phone];Laboratorio de Síntesis y Diseño Molecular, Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo. Edificio B-1, Ciudad Universitaria, Morelia, Michoacán, México. CP 58030, tel.: [phone];

关键词: 4-aminoantipyrine;    arylboronic acids;    biaryls;    cross-coupling;    palladium(II) complex;   

DOI  :  10.3762/bjoc.10.299

来源: DOAJ

【 摘 要 】

A simple and efficient catalytic system based on a Pd complex of 4-aminoantipyrine, 4-AAP–Pd(II), was found to be highly active for Suzuki–Miyaura cross-coupling of aryl iodides and bromides with phenylboronic acids under mild reaction conditions. Good to excellent product yields from the cross-coupling reaction can be achieved when the reaction is carried out in ethanol, in the open air, using low loading of 4-AAP–Pd(II) as a precatalyst, and in the presence of aqueous K2CO3 as the base. A variety of functional groups are tolerated.

【 授权许可】

Unknown