A Quantitative Electroencephalography Study on Cochlear Implant-Induced Cortical Changes in Single-Sided Deafness with Tinnitus

Frontiers in Human Neuroscience

Kyung-Joon Park¹  Kyungsoo Kim¹  Ji-Woong Choi¹  Paul Van de Heyning²  Griet Mertens²  Sang-Youp Lee³  Jae-Jin Song³  Woongsang Sunwoo³  Hongsoo Choi⁴  Dirk De Ridder⁵  Sven Vanneste⁶ 

[1] Department of Information and Communication Engineering, Daegu Gyeongbuk Institute of Science and Technology, Daegu, South Korea;Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Antwerp, Edegem, Belgium;Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea;Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology, Daegu, South Korea;Department of Surgical Sciences, Section of Neurosurgery, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand;Lab for Clinical and Integrative Neuroscience, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX, USA;

关键词: single side deafness;    tinnitus;    cochlear implantation;    electroencephalography;    dynamic peripheral reafferentation;   

DOI  :  10.3389/fnhum.2017.00210

来源: DOAJ

【 摘 要 】

The mechanism of tinnitus suppression after cochlear implantation (CI) in single-sided deafness (SSD) is not fully understood. In this regard, by comparing pre- and post-CI quantitative electroencephalography (qEEG), we explored cortical changes relevant to tinnitus improvement. In SSD patients who underwent CI, qEEG data were collected: (1) before CI, (2) 6 months post-operatively with CI-on, and (3) 30 min after CI-off and source-localized cortical activity/functional connectivity analyses were performed. Compared to the pre-operative baseline, the CI-on condition demonstrated significantly decreased activity in the right auditory- and orbitofrontal cortices (OFC) for the delta frequency band as well as decreased connectivity between the auditory cortex/posterior cingulate cortex for the delta/beta2 bands. Meanwhile, compared to the CI-off condition, the CI-on condition displayed decreased activity in the right auditory cortices/OFC for the delta band, and in bilateral auditory cortices, left inferior frontal cortex/OFC for the gamma band. However, qEEG analyses showed no significant differences between the CI-off and baseline conditions. CI induced overall decreased cortical activity and functional connectivity. However, judging from no differences between the CI-off and baseline conditions, CI-induced cortical activity and functional connectivity changes are not by cortical plastic changes, but by dynamic peripheral reafferentation.

【 授权许可】

Unknown