Frontiers in Cardiovascular Medicine | |
Acute Lesion Imaging in Predicting Chronic Tissue Injury in the Ventricles | |
Mihail Chelu1  Eugene Kholmovski2  Michel Barakat3  Takano Yamaguchi4  Aneesh Dhorepatil5  Charbel Noujaim5  Saihariharan Nedunchezhian5  Chao Huang5  Christopher Pottle5  Mario Mekhael5  Abdel Hadi El Hajjar5  Lilas Dagher5  Yichi Zhang5  Tarek Ayoub5  Nassir Marrouche5  | |
[1] Baylor Heart Clinic, Baylor College of Medicine, Houston, TX, United States;Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States;Department of Cardiology, PeaceHealth, Bellingham, WA, United States;Department of Cardiology, Saga University, Saga, Japan;Tulane Research Innovation for Arrhythmia Discoveries, Tulane University School of Medicine, New Orleans, LA, United States; | |
关键词: arrhythmia; ventricular ablation; catheter ablation; animal model; electrophysiology; | |
DOI : 10.3389/fcvm.2021.791217 | |
来源: DOAJ |
【 摘 要 】
BackgroundChronic lesion formation after cardiac tissue ablation is an important indicator for procedural outcome. Moreover, there is a lack of knowledge regarding the features that predict chronic lesion formation.ObjectiveThe aim of this study is to determine whether acute lesion visualization using late gadolinium enhanced magnetic resonance imaging (LGE-MRI) can reliably predict chronic lesion size.MethodsFocal lesions were created in left and right ventricles of canine models using either radiofrequency (RF) ablation or cryofocal ablation. Multiple ablation parameters were used. The first LGE-MRI was acquired within 1–5 h post-ablation and the second LGE-MRI was obtained 47–82 days later. Corview software was used to perform lesion segmentations and size calculations.Results:Fifty-Five lesions were created in different locations in the ventricles. Chronic volume size decreased by a mean of 62.5 % (95% CI 58.83–67.97, p < 0.0005). Similar regression of lesion volume was observed regardless of ablation location (p = 0.32), ablation technique (p = 0.94), duration (p = 0.37), power (p = 0.55) and whether lesions were connected or not (p = 0.35). There was no significant difference in lesion volume reduction assessed at 47–54 days and 72–82 days after ablation (p = 0.31). Chronic lesion volume was equal to 0.32 of the acute lesion volumes (R2 = 0.75).ConclusionChronic tissue injury related to catheter ablation can be reliably modeled as a linear function of the acute lesion volume as assessed by LGE-MRI, regardless of the ablation parameters.
【 授权许可】
Unknown