A Single 60.000 IU Dose of Erythropoietin Does Not Improve Short-Term Aerobic Exercise Performance in Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled Crossover Trial

Frontiers in Physiology

Thomas Haider¹  Victor Diaz²  Markus Thiersch²  Maria Alvarez-Sanchez²  Christina M. Spengler³  Jamie Albert³  Matthias P. Hilty⁴  Marco Maggiorini⁴  Max Gassmann⁵ 

[1] Department of Cardiology, University Hospital Zürich, Zurich, Switzerland;Institute for Veterinary Physiology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland;Institute of Human Movement Science and Sport, ETH Zürich, Zurich, Switzerland;Institute of Intensive Care Medicine, University Hospital of Zürich, Zurich, Switzerland;Zurich Center for Integrative Human Physiology (ZIHP), Zurich, Switzerland;

关键词: EPO;    high dose;    oxygen transport;    erythropoiesis;    doping;   

DOI  :  10.3389/fphys.2020.537389

来源: DOAJ

【 摘 要 】

Erythropoietin (EPO) boosts exercise performance through increase in oxygen transport capacity following regular administration of EPO but preclinical study results suggest that single high dose of EPO also may improve exercise capacity. Twenty-nine healthy subjects (14 males/15 females; age: 25 ± 3 years) were included in a randomized, double-blind, placebo-controlled crossover study to assess peak work load and cardiopulmonary variables during submaximal and maximal cycling tests following a single dose of 60.000 IU of recombinant erythropoietin (EPO) or placebo (PLA). Submaximal exercise at 40%/60% of peak work load revealed no main effect of EPO on oxygen uptake (27.9 ± 8.7 ml min–1⋅kg–1/ 37.1 ± 13.2 ml min–1⋅kg–1) versus PLA (25.2 ± 3.7 ml min–1⋅kg–1/ 33.1 ± 5.3 ml min–1⋅kg–1) condition (p = 0.447/p = 0.756). During maximal exercise peak work load (PLA: 3.5 ± 0.6 W⋅kg–1 vs. EPO: 3.5 ± 0.6 W kg–1, p = 0.892) and peak oxygen uptake (PLA: 45.1 ± 10.4 ml⋅min–1 kg–1 vs. EPO: 46.1 ± 14.2 ml⋅min–1 kg–1, p = 0.344) reached comparable values in the two treatment conditions. Other cardiopulmonary variables (ventilation, cardiac output, heart rate) also reached similar levels in the two treatment conditions. An interaction effect was found between treatment condition and sex resulting in higher peak oxygen consumption (p = 0.048) and ventilation (p = 0.044) in EPO-treated males. In conclusion, in a carefully conducted study using placebo-controlled design the present data failed to support the hypothesis that a single high dose of EPO has a measurable impact on work capacity in healthy subjects.

【 授权许可】

Unknown