Radiotherapy and Cytokine Storm: Risk and Mechanism

Frontiers in Oncology

Shumei Ma¹  Xiaodong Liu¹  Zhenzhen Liang²  Chen Zhang³ 

[1] Key Laboratory of Watershed Science and Health of Zhejiang Province, Wenzhou Medical University, Wenzhou, China;NHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, China;School of Public Health and Management, Wenzhou Medical University, Wenzhou, China;

关键词: radiotherapy;    cytokine storm;    radiotherapy—adverse effects;    immune activation;    immune suppression;    dose limitation;   

DOI  :  10.3389/fonc.2021.670464

来源: DOAJ

【 摘 要 】

Radiotherapy (RT) shows advantages as one of the most important precise therapy strategies for cancer treatment, especially high-dose hypofractionated RT which is widely used in clinical applications due to the protection of local anatomical structure and relatively mild impairment. With the increase of single dose, ranging from 2~20 Gy, and the decrease of fractionation, the question that if there is any uniform standard of dose limits for different therapeutic regimens attracts more and more attention, and the potential adverse effects of higher dose radiation have not been elucidated. In this study, the immunological adverse responses induced by radiation, especially the cytokine storm and the underlying mechanisms such as DAMPs release, pro-inflammatory cytokine secretion and cGAS-STING pathway activation, will be elucidated, which contributes to achieving optimal hypofractionated RT regimen, improving the killing of cancer cells and avoiding the severe side effects.

【 授权许可】

Unknown