Computational Study of Post Translation Modification in Chimeric Virus Like Particles Vaccine of Human Papilloma Virus with Virion Capsid L1

Makara Seri Sains

关键词: cVLP;    HPV;    Cervical Cancer;    Vaccine;    Post Translation Modification;    host;   

DOI  :  

来源: DOAJ

【 摘 要 】

The Human Papillomavirus (HPV) infection has a tight correlation with the incidence of cervical cancer. Chimeric virus like particles (cVLP) has been developed as vaccine candidate for preventing cervical cancer. cVLPs are improvement of Virus Like Particles (VLP) by substituting the epitope of L1 HPV -18 and -52 protein to L1 HPV -16 protein. They are ANN1, ANN2, HMM1, and HMM2. The impact of post translation modification will be determined. Based on In Silico study, the dominant post translation modification is glycosylation.

【 授权许可】

Unknown