HPV infection screening using surface plasmon resonance in women from Kunming (southwest China)

Bosnian Journal of Basic Medical Sciences

YueQuan¹  YajuanHuang²  QingQing²  Honglin Zhou²  ChunyiSun²  YangLiu²  DaizhuLi²  ChangjunXu² 

[1] Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xiamen University, Xiamen Fujian, China;Department of Reproductive, The Second Affiliated Hospital of Kunming Medical University, Kunming Yunnan, China;

关键词: Cervical cancer;    screening;    human papilloma virus;    HPV;    surface plasmon resonance;    SPR;   

DOI  :  10.17305/bjbms.2019.4352

来源: DOAJ

【 摘 要 】

No study examined the frequency of human papillomavirus (HPV) genotypes by surface plasmon resonance (SPR) in southwest China. This was a cross-sectional survey (The Second Affiliated Hospital of Kunming Medical University, 10/2010 to 12/2011) in 150 patients who were hospitalized or volunteered for cervical cancer (CC) screening. A HPV typing kit was used to detect 24 types of HPV by the SPR technique. The HPV-positive rate was 34.8% in women with normal cytology and 92.9% in women with CC. The frequency of HPV16 increased from 9.4% for women with normal cytology to 28.9% for cervical intraepithelial neoplasia (CIN)1, 41.4% for CIN2, 54.1% for CIN3, and 71.4% for CC (p < 0.001). The frequency of HPV18 increased from 0% for women with normal cytology to 2.6% for CIN1, 3.4% for CIN2, 5.4% for CIN3, and 21.4% for CC (p = 0.03). HPV40 was only found in one patient with CC (p = 0.04). There was no relation between HPV genotype and women’s age. In Kunming (southwest China), the frequency of HPV infection was 74.0% among women who underwent CC screening. HPV16 and HPV18 were the two most frequent genotypes. SPR could be of value for the screening of HPV infection.

【 授权许可】

Unknown