Glycolipids and other lipid constituents of normal human liver

Journal of Lipid Research

Peter O. Kwiterovich, Jr.¹  Donald S. Fredrickson¹  Howard R. Sloan¹ 

[1] Molecular Disease Branch, National Heart and Lung Institute, National Institutes of Health, Bethesda, Maryland 20014;

关键词: cholesterol;    triglyceride;    phospholipid;    neutral glycolipids;    gangliosides;    hematoside;   

DOI  :  

来源: DOAJ

【 摘 要 】

An analysis of the lipids in normal human liver is presented which is particularly designed to assist in the classification and study of lipid-storage diseases. Special emphasis has been given to a determination of the quantity and composition of the neutral glycolipid classes and predominant ganglioside (Gm3). The neutral glycolipid content of 0.19 (sd ± 0.11) μmoles per g wet tissue, represented 0.4% of the total lipid in liver. Ceramide dihexoside was the most abundant neutral glycolipid. The mean contents of cholesterol, glycerides, and total phospholipids were 3.9, 19.5, and 25.1 mg/g wet weight, respectively. The relative amounts of seven different phospholipid classes were also determined; these included cardiolipin (diphosphatidylglycerol), which constituted 3.9% of the liver phospholipids.

【 授权许可】

Unknown