Friend of the Devil: Negative Social Influences Driving Substance Use Disorders

Frontiers in Behavioral Neuroscience

Rajani Maiya¹  Franciely Paliarin¹  Matthew B. Pomrenze² 

[1] Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, LA, United States;Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, United States;

关键词: social defeat;    serotonin;    kappa opioid receptor;    social isolation;    substance use disorders;    hyperkatifeia;   

DOI  :  10.3389/fnbeh.2022.836996

来源: DOAJ

【 摘 要 】

Substance use disorders in humans have significant social influences, both positive and negative. While prosocial behaviors promote group cooperation and are naturally rewarding, distressing social encounters, such as aggression exhibited by a conspecific, are aversive and can enhance the sensitivity to rewarding substances, promote the acquisition of drug-taking, and reinstate drug-seeking. On the other hand, withdrawal and prolonged abstinence from drugs of abuse can promote social avoidance and suppress social motivation, accentuating drug cravings and facilitating relapse. Understanding how complex social states and experiences modulate drug-seeking behaviors as well as the underlying circuit dynamics, such as those interacting with mesolimbic reward systems, will greatly facilitate progress on understanding triggers of drug use, drug relapse and the chronicity of substance use disorders. Here we discuss some of the common circuit mechanisms underlying social and addictive behaviors that may underlie their antagonistic functions. We also highlight key neurochemicals involved in social influences over addiction that are frequently identified in comorbid psychiatric conditions. Finally, we integrate these data with recent findings on (±)3,4-methylenedioxymethamphetamine (MDMA) that suggest functional segregation and convergence of social and reward circuits that may be relevant to substance use disorder treatment through the competitive nature of these two types of reward. More studies focused on the relationship between social behavior and addictive behavior we hope will spur the development of treatment strategies aimed at breaking vicious addiction cycles.

【 授权许可】

Unknown