What’s next in cancer immunotherapy? - The promise and challenges of neoantigen vaccination

OncoImmunology

Bruce W. S. Robinson¹  Alec J. Redwood¹  Ian M. Dick¹  Jenette Creaney¹ 

[1] University of Western Australia;

关键词: neoantigen;    immunotherapy;    vaccine;    neoantigen vaccine;   

DOI  :  10.1080/2162402X.2022.2038403

来源: DOAJ

【 摘 要 】

The process of tumorigenesis leaves a series of indelible genetic changes in tumor cells, that when expressed, have the potential to be tumor-specific immune targets. Neoantigen vaccines that capitalize on this potential immunogenicity have shown efficacy in preclinical models and have now entered clinical trials. Here we discuss the status of personalized neoantigen vaccines and the current major challenges to this nascent field. In particular, we focus on the types of antigens that can be targeted by vaccination and on the role that preexisting immunosuppression, and in particular T-cell exhaustion, will play in the development of effective cancer vaccines.

【 授权许可】

Unknown