Comparison of Diffusion Kurtosis Imaging and Amide Proton Transfer Imaging in the Diagnosis and Risk Assessment of Prostate Cancer

Frontiers in Oncology

Zhansheng Zhai¹  Huijia Yin¹  Xingxing Jin¹  Dongming Han¹  Jinhui Duan¹  Ruifang Yan¹  Ying Hu¹  Jian Zhang¹  Dongdong Wang²  Kaiyu Wang³ 

[1] Department of MR, The First Affiliated Hospital, Xinxiang Medical University, Weihui, China;Department of Radiology, People’s Hospital of Zhengzhou, Zhengzhou, China;MR Research China, GE Healthcare, Beijing, China;

关键词: diffusion kurtosis imaging;    amide proton transfer;    prostate cancer;    Gleason score;    benign prostatic hyperplasia;   

DOI  :  10.3389/fonc.2021.640906

来源: DOAJ

【 摘 要 】

ObjectivesThis study aims to evaluate and compare the diagnostic value of DKI and APT in prostate cancer (PCa), and their correlation with Gleason Score (GS).Materials and MethodsDKI and APT imaging of 49 patients with PCa and 51 patients with benign prostatic hyperplasia (BPH) were collected and analyzed, respectively. According to the GS, the patients with PCa were divided into high-risk, intermediate-risk and low-risk groups. The mean kurtosis (MK), mean diffusion (MD) and magnetization transfer ratio asymmetry (MTRasym, 3.5 ppm) values among PCa, BPH, and different GS groups of PCa were compared and analyzed respectively. The diagnostic accuracy of each parameter was evaluated by using the receiver operating characteristic (ROC) curve. The correlation between each parameter and GS was analyzed by using Spearman’s rank correlation.ResultsThe MK and MTRasym (3.5 ppm) values were significantly higher in PCa group than in BPH group, while the MD value was significantly lower than in BPH group. The differences of MK/MD/MTRasym (3.5 ppm) between any two of the low-risk, intermediate-risk, and high-risk groups were all statistically significant (p <0.05). The MK value showed the highest diagnostic accuracy in differentiating PCa and BPH, BPH and low-risk, low-risk and intermediate-risk, intermediate-risk and high-risk (AUC = 0.965, 0.882, 0.839, 0.836). The MK/MD/MTRasym (3.ppm) values showed good and moderate correlation with GS (r = 0.844, −0.811, 0.640, p <0.05), respectively.ConclusionDKI and APT imaging are valuable in the diagnosis of PCa and demonstrate strong correlation with GS, which has great significance in the risk assessment of PCa.

【 授权许可】

Unknown