Cerebroprotein hydrolysate‐I protects senescence‐induced by D‐galactose in PC12 cells and mice

Food Science & Nutrition

Qinghua Zhang¹  Xiaolin Wu²  Lin Zhu²  Yunliang Guo²  Yingjuan Liu²  Yuqian Ren²  Leiming Ren³ 

[1] Department of Neurology Shandong Second Provincial General Hospital Jinan China;Institute of Cerebrovascular Diseases Taishan Scholars Construction Project Excellent Innovative Team of Shandong Province Medical Research Center The Affiliated Hospital of Qingdao University Qingdao China;Institute of Chinese Integrative Medicine Hebei Medical University Shijiazhuang China;

关键词: cerebroprotein hydrolysate‐I;    D‐galactose;    mice;    PC12 cells;    senescence;    telomerase;   

DOI  :  10.1002/fsn3.2333

来源: DOAJ

【 摘 要 】

Abstract Cerebroprotein hydrolysate‐I (CH‐I)，a mixture of peptides extracted from porcine brain tissue，has shown a neuroprotective effect, but its role in brain senescence is unclear. In the present study, we established a senescence model of PC12 cells and mice to investigate the effect of CH‐I on brain senescence via JAK2/STAT3 pathway. The results showed that CH‐I could improve cell viability, inhibit the apoptosis of cells, and reduce the senescence‐positive cells induced by D‐galactose. In vivo, CH‐I improved the learning ability and memory of aging mice, reduced neuronal damage in mice hippocampus. Mechanism studies showed that CH‐I could adjust BDNF protein expressions, activate JAK2/STAT3 pathway, and finally enhance telomerase activity. All these findings indicated that CH‐I showed a neuroprotective effect against brain senescence. These results might provide further reference and support for the application of CH‐I in delaying aging.

【 授权许可】

Unknown