Ubiquitin and Ubiquitin-like Proteins in Cancer, Neurodegenerative Disorders, and Heart Diseases

International Journal of Molecular Sciences

Changwon Kho¹  Jin-Taek Hwang²  Ahyoung Lee³ 

[1] Division of Applied Medicine, School of Korean Medicine, Pusan National University, Yangsan 50612, Korea;Food Functionality Research Division, Korea Food Research Institute, Jeonju 55365, Korea;Institute of Korean Medicine, School of Korean Medicine, Pusan National University, Yangsan 50612, Korea;

关键词: post-translational modification;    ubiquitin;    ubiquitin-like proteins;    ubiquitin-proteasome system;    disease association and progression;   

DOI  :  10.3390/ijms23095053

来源: DOAJ

【 摘 要 】

Post-translational modification (PTM) is an essential mechanism for enhancing the functional diversity of proteins and adjusting their signaling networks. The reversible conjugation of ubiquitin (Ub) and ubiquitin-like proteins (Ubls) to cellular proteins is among the most prevalent PTM, which modulates various cellular and physiological processes by altering the activity, stability, localization, trafficking, or interaction networks of its target molecules. The Ub/Ubl modification is tightly regulated as a multi-step enzymatic process by enzymes specific to this family. There is growing evidence that the dysregulation of Ub/Ubl modifications is associated with various diseases, providing new targets for drug development. In this review, we summarize the recent progress in understanding the roles and therapeutic targets of the Ub and Ubl systems in the onset and progression of human diseases, including cancer, neurodegenerative disorders, and heart diseases.

【 授权许可】

Unknown