Three Novel Triterpenoids from Taraxacum officinale Roots

Molecules

Takashi Kikuchi¹  Takeshi Yamada¹  Ayaka Tanaka¹  Reiko Tanaka¹  Mayu Uriuda¹ 

[1] Laboratory of Medicinal Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan;

关键词: 18β,19β-epoxy-21β-methoxylupan-3β-yl acetate;    3β-acetoxybauer-7-en-6-one;    3β-acetoxyeuph-7,24-dien-6-one;    Taraxacum officinale;    dandelion;    triterpene;    NO production;   

DOI  :  10.3390/molecules21091121

来源: DOAJ

【 摘 要 】

Three novel lupane-, bauerane-, and euphane-type triterpenoids (1–3), in addition to seven known triterpenoids (4–10)—18β,19β-epoxy-21β-hydroxylupan-3β-yl acetate (4), 21-oxolup-18-en-3β-yl acetate (5), betulin (6), officinatrione (7), 11α-methoxyolean-12-en-3-one (8), eupha-7,24-dien-3-one (9), and 24-oxoeupha-7,24-dien-3β-yl acetate (10)—were isolated from the roots of Taraxacum officinale. Their structures were elucidated on the basis of spectroscopic analyses using 1D and 2D-NMR spectra and electron ionization mass spectrometry (EIMS). The effects of compounds 1–10 on the production of nitric oxide (NO) in lipopolysaccharide (LPS)-activated mouse peritoneal macrophages were evaluated. Compounds 4, 6, and 10 exhibited similar NO inhibitory activities to NG-monomethyl-l-arginine acetate (l-NMMA). These compounds did not exhibit cytotoxicity at an effective concentration. The results of present study suggest that compounds 4, 6, and 10 have potential as anti-inflammatory disease agents.

【 授权许可】

Unknown