A Fermented Food Product Containing Lactic Acid Bacteria Protects ZDF Rats from the Development of Type 2 Diabetes

Nutrients

Miriam Araña¹  Miriam Cabello-Olmo¹  Miguel Barajas¹  IgnacioJ. Encio¹  Maria Oneca¹  Neira Sainz²  MaríaJ. Moreno-Aliaga²  Elizabeth Guruceaga³  Paloma Torre⁴  JesúsVicente Díaz⁵ 

[1] Biochemistry Area, Department of Health Science, Public University of Navarre, 31008 Pamplona, Spain;Department of Nutrition Food Sciences and Physiology, Center for Nutrition Research, University of Navarra, 31008 Pamplona, Spain;IDISNA, Navarra’s Health Research Institute, 31008 Pamplona, Spain;Nutrition and Bromatology area, Department of Natural Sciences, Public University of Navarre, 31006 Pamplona, Spain;Pentabiol S.L., Polígono Noain-Esquiroz s/n, 31191 Pamplona, Spain;

关键词: diabetes;    fermented food;    gut microbiota;    lactic acid bacteria;    postbiotic;    probiotic;   

DOI  :  10.3390/nu11102530

来源: DOAJ

【 摘 要 】

Type 2 diabetes (T2D) is a complex metabolic disease, which involves a maintained hyperglycemia due to the development of an insulin resistance process. Among multiple risk factors, host intestinal microbiota has received increasing attention in T2D etiology and progression. In the present study, we have explored the effect of long-term supplementation with a non-dairy fermented food product (FFP) in Zucker Diabetic and Fatty (ZDF) rats T2D model. The supplementation with FFP induced an improvement in glucose homeostasis according to the results obtained from fasting blood glucose levels, glucose tolerance test, and pancreatic function. Importantly, a significantly reduced intestinal glucose absorption was found in the FFP-treated rats. Supplemented animals also showed a greater survival suggesting a better health status as a result of the FFP intake. Some dissimilarities have been observed in the gut microbiota population between control and FFP-treated rats, and interestingly a tendency for better cardiometabolic markers values was appreciated in this group. However, no significant differences were observed in body weight, body composition, or food intake between groups. These findings suggest that FFP induced gut microbiota modifications in ZDF rats that improved glucose metabolism and protected from T2D development.

【 授权许可】

Unknown