Region-Specific Biomarkers and Their Mechanisms in the Treatment of Lung Adenocarcinoma: A Study of Panax quinquefolius from Wendeng, China

Molecules

Peihai Li¹  Xuanming Zhang¹  Mengqi Zhang¹  Kechun Liu¹  Lizhen Wang¹  Yun Zhang¹  Jie Chu¹  Shanshan Zhang¹  Xiaobin Li¹  Liwen Han²  Pengfei Tu³ 

[1] Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province, Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China;Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 256200, China;State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China;

关键词: Panax quinquefolius;    biomarkers;    network pharmacology;    molecular docking;    protein phosphorylation;   

DOI  :  10.3390/molecules26226829

来源: DOAJ

【 摘 要 】

Panax quinquefolius, a popular medicinal herb, has been cultivated in China for many years. In this work, the region-specific profiles of metabolites in P. quinquefolius from Wendeng was investigated using liquid-chromatography–quadrupole–time-of-flight-(LC–Q–TOF)-based metabolomics analysis. The three most abundant biomarkers, identified as ginsenoside Rb₃, notoginsenoside R₁, and ginsenoside Rc, were the representative chemical components employed in the network pharmacology analysis. In addition, molecular docking and western blotting analyses revealed that the three compounds were effective binding ligands with Hsp90α, resulting in the inactivation of SRC and PI3K kinase, which eventually led to the inactivation of the Akt and ERK pathways and lung cancer suppression. The outcomes obtained herein demonstrated the intriguing chemical characteristics and potential functional activities of P. quinquefolius from Wendeng.

【 授权许可】

Unknown