Molecular Insight into the Therapeutic Promise of Flavonoids against Alzheimer’s Disease

Molecules

Lotfi Aleya¹  KannanR.R. Rengasamy²  Abdur Rauf³  Kamal Niaz⁴  Md.Tanvir Kabir⁵  Md.Sahab Uddin⁶  Bijo Mathew⁷  Eduardo Sobarzo-Sánchez⁸  GhulamMd Ashraf⁹  Philippe Jeandet^1,10  Christophe Clément^1,10 

[1] Chrono-Environnement Laboratory, UMR CNRS 6249, Bourgogne Franche-Comté University, F-25030 Besançon, France;Department of Bioresources and Food Sciences, Konkuk University, Seoul 05029, Korea;Department of Chemistry, University of Swabi, Anbar 23561, Khyber Pakhtunkhwa, Pakistan;Department of Pharmacology and Toxicology, Faculty of Bio-Sciences, Cholistan University of Veterinary and Animal Sciences (CUVAS), Bahawalpur 63100, Pakistan;Department of Pharmacy, BRAC University, Dhaka 1212, Bangladesh;Department of Pharmacy, Southeast University, Dhaka 1213, Bangladesh;Division of Drug Design and Medicinal Chemistry Research Lab, Department of Pharmaceutical Chemistry, Ahalia School of Pharmacy, Palakkad, Kerala 678557, India;Instituto de Investigación e Innovación en Salud, Facultad de Ciencias de la Salud, Universidad Central de Chile, Santiago 8330507, Chile;King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia;Research Unit, Induced Resistance and Plant Bioprotection, EA 4707, SFR Condorcet FR CNRS 3417, Faculty of Sciences, University of Reims Champagne-Ardenne, PO Box 1039, 51687 Reims CEDEX 2, France;

关键词: alzheimer’s disease;    flavonoids;    amyloid plaque;    neurofibrillary tangles;    pi3k/akt signaling;    mapk signaling;    mtor;   

DOI  :  10.3390/molecules25061267

来源: DOAJ

【 摘 要 】

Alzheimer’s disease (AD) is one of the utmost chronic neurodegenerative disorders, which is characterized from a neuropathological point of view by the aggregates of amyloid beta (Aβ) peptides that are deposited as senile plaques and tau proteins which form neurofibrillary tangles (NFTs). Even though advancement has been observed in order to understand AD pathogenesis, currently available therapeutic methods can only deliver modest symptomatic relief. Interestingly, naturally occurring dietary flavonoids have gained substantial attention due to their antioxidative, anti-inflammatory, and anti-amyloidogenic properties as alternative candidates for AD therapy. Experimental proof provides support to the idea that some flavonoids might protect AD by interfering with the production and aggregation of Aβ peptides and/or decreasing the aggregation of tau. Flavonoids have the ability to promote clearance of Aβ peptides and inhibit tau phosphorylation by the mTOR/autophagy signaling pathway. Moreover, due to their cholinesterase inhibitory potential, flavonoids can represent promising symptomatic anti-Alzheimer agents. Several processes have been suggested for the aptitude of flavonoids to slow down the advancement or to avert the onset of Alzheimer’s pathogenesis. To enhance cognitive performance and to prevent the onset and progress of AD, the interaction of flavonoids with various signaling pathways is proposed to exert their therapeutic potential. Therefore, this review elaborates on the probable therapeutic approaches of flavonoids aimed at averting or slowing the progression of the AD pathogenesis.

【 授权许可】

Unknown