Spray Drying for Direct Compression of Pharmaceuticals

Processes

Ahmad Aljaberi¹  Ioannis Nikolakakis²  Nizar Al-Zoubi³  Shadi Gharaibeh⁴ 

[1] Department of Pharmaceutical Sciences and Pharmaceutics, Faculty of Pharmacy, Applied Science Private University, Amman 11931, Jordan;Department of Pharmaceutical Technology, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece;Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, The Hashemite University, Zarqa 13133, Jordan;Faculty of Pharmacy, Jerash University, Jerash 26150, Jordan;

关键词: spray drying;    direct compression;    tablets;    co-processing;    multifunctional;    sustained release;   

DOI  :  10.3390/pr9020267

来源: DOAJ

【 摘 要 】

Tableting by direct compression (DC) is one of the simplest and most cost-effective drug manufacturing approaches. However, most active pharmaceutical ingredients (APIs) and excipients lack the compression and flow properties required to meet the needs of high-speed industrial tablet presses. Therefore, the majority of DC APIs and excipients are modified via processing/co-processing particle engineering techniques to boost their properties. Spray drying is one of the most commonly employed techniques to prepare DC grades of APIs and excipients with prominent advantages. This review aims to present an overview of the commercially marketed and investigationally-prepared DC APIs and excipients produced by spray drying.

【 授权许可】

Unknown