Sex Differences in Ischemic Stroke Within the Younger Age Group: A Register-Based Study

Frontiers in Neurology

Mia von Euler¹  Marie Eriksson²  Kristina Norman³ 

[1] Department of Neurology and Rehabilitation, School of Medicine, Örebro University, Örebro, Sweden;Department of Statistics, USBE, Umeå University, Umeå, Sweden;School of Medicine, Örebro University, Örebro, Sweden;

关键词: ischemic stroke;    register;    sex differences;    younger population;    cerebrovascular disease;   

DOI  :  10.3389/fneur.2022.793181

来源: DOAJ

【 摘 要 】

BackgroundStroke incidence is decreasing in most developing countries. However, worrisome trends of an increase in the younger population have been described.AimTo investigate sex differences and longitudinal changes in ischemic stroke regarding incidence, cardiovascular risk factors, and outcome, in the young.MethodsThis is an observational study based on the data from the Swedish national stroke registry, Riksstroke. Patients, 18–54 years of age, having ischemic stroke between 2005 and 2018 were included, resulting in a study population of 16,210 patients.ResultsThe incidence was higher in men than in women (30.6 vs. 19.1 per 100,000, P < 0.001). After an initial increase, the incidence stabilized and then decreased, resulting in a similar level in 2018 as in 2005. Atrial fibrillation, diabetes, and usage of anti-hypertensives at stroke onset were more common among men and did not change over time. Smoking was common and slightly more so in women, but with a reduced prevalence in both men and women during the study period. Dependency in Activities of Daily Living (ADL) and case fatality showed no clear trends or sex differences.ConclusionsThe results show that there are sex differences in ischemic stroke in the younger age group regarding incidence and vascular risk factors, particularly smoking. Temporal trends in stroke incidence are difficult to interpret as fluctuations are substantial, largely due to stroke being quite uncommon in the younger population.

【 授权许可】

Unknown