Astaxanthin supplementation effects on adipocyte size and lipid profile in OLETF rats with hyperphagia and visceral fat accumulation

Journal of Functional Foods

Hideki Yamauchi¹  Mayuko Iida²  Masato Suzuki³  Hidetsugu Saito⁴  Yoshimasa Saito⁵  Masaki Kimura⁶  Toshiaki Shibasaki⁶ 

[1] Corresponding author. Department of Pharmacotherapeutics, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan. Tel.: [phone];Department of Metabolic Medicine, Mater Medical Research Institute, University of Queensland, 37 Kent Street, Woolloongabba, Queensland 4102, Australia;fax: [phone].;Department of Laboratory Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo 105-8461, Japan;Department of Molecular Physiology, The Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo 105-8461, Japan;Department of Pharmacotherapeutics, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan;

关键词: Astaxanthin;    Supplementation;    Visceral fat;    Adipocyte size;    Lipid profile;    Lipid oxidation;   

DOI  :  

来源: DOAJ

【 摘 要 】

The effects of astaxanthin supplementation on visceral adipose tissue and lipid profile in an Otsuka Long Evans Tokushima Fatty (OLETF) rat model of hyperphagia and visceral fat accumulation was investigated. At 25 weeks of age, OLETF rats were assigned randomly to an obese control (OC, n = 6) or an astaxanthin supplementation (AX, n = 6) group. Long Evans Tokushima Otsuka (LETO) rats were assigned to a lean control (LT, n = 6) group. The AX group was subjected to 6 weeks of dietary supplementation with 0.2% astaxanthin (2 g/kg diet powder chow food) ad libitum. After the 6-week experimental period, astaxanthin supplementation in obese rats promoted size reduction of visceral adipocytes, with a remarkable decrease in FFA and a significant increase in blood HDL-c concentrations. These results suggest that astaxanthin can at least partially ameliorate lipid profile and adipocyte abnormalities associated with obesity.

【 授权许可】

Unknown