Uninterrupted Dabigatran Administration Provides Greater Inhibition against Intracardiac Activation of Hemostasis as Compared to Vitamin K Antagonists during Cryoballoon Catheter Ablation of Atrial Fibrillation

Journal of Clinical Medicine

Edit Fiak¹  Orsolya Hajas¹  Alexandra Kiss¹  László Nagy¹  Réka Urbancsek¹  Zoltán Csanádi¹  János Kappelmayer²  KittiBernadett Kovács³  Attila Nagy⁴  Zsuzsa Bagoly⁵  Ferenc Sarkady⁵  NoémiKlára Tóth⁵  Rita Orbán-Kálmándi⁵  László Csiba⁶ 

[1] Department of Cardiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary;Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary;Department of Neurology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary;Department of Preventive Medicine, Faculty of Public Health, University of Debrecen, 4028 Debrecen, Hungary;Division of Clinical Laboratory Sciences, Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary;MTA-DE Cerebrovascular and Neurodegenerative Research Group, 4032 Debrecen, Hungary;

关键词: atrial fibrillation;    cryoballoon ablation;    dabigatran;    vitamin K antagonists;   

DOI  :  10.3390/jcm9093050

来源: DOAJ

【 摘 要 】

Background. Cerebral thromboembolism is a rare but feared complication of transcatheter ablation in patients with atrial fibrillation (AF). Here, we aimed to test which pre-procedural anticoagulation strategy results in less intracardiac activation of hemostasis during ablation. Patients and methods. In this observational study, 54 paroxysmal/persistent AF patients undergoing cryoballoon ablation were grouped according to their periprocedural anticoagulation strategy: no anticoagulation (oral anticoagulation (OAC) free; n = 24), uninterrupted vitamin K antagonists (VKA) (n = 11), uninterrupted dabigatran (n = 17). Blood was drawn from the left atrium before and immediately after the ablation procedure. Cryoablations were performed according to standard protocols, during which heparin was administered. Heparin-insensitive markers of hemostasis and endothelial damage were tested from intracardiac samples: D-dimer, quantitative fibrin monomer (FM), plasmin-antiplasmin complex (PAP), von Willebrand factor (VWF) antigen, chromogenic factor VIII (FVIII) activity. Results. D-dimer increased significantly in all groups post-ablation, with lowest levels in the dabigatran group (median [interquartile range]: 0.27 [0.36] vs. 1.09 [1.30] and 0.74 [0.26] mg/L in OAC free and uninterrupted VKA groups, respectively, p < 0.001). PAP levels were parallel to this observation. Post-ablation FM levels were elevated in OAC free (26.34 [30.04] mg/L) and VKA groups (10.12 [16.01] mg/L), but remained below cut-off in all patients on dabigatran (3.98 [2.0] mg/L; p < 0.001). VWF antigen and FVIII activity increased similarly post-ablation in all groups, suggesting comparable procedure-related endothelial damage. Conclusion. Dabigatran provides greater inhibition against intracardiac activation of hemostasis as compared to VKAs during cryoballoon catheter ablation.

【 授权许可】

Unknown