A NEW COMBINATION INHIBITS INTESTINAL CHOLESTEROL ABSORPTION, SUPPRESSES ENDOGENOUS CHOLESTEROL SYNTHESIS, AND DEMONSTRATES ANTI-INFLAMMATORY AND HEPATOPROTECTIVE EFFECTS

Кардиоваскулярная терапия и профилактика

V. Yu. Gorbacheva¹  S. I. Chernova¹  R. G. Oganov¹ 

[1] State Research Centre for Preventive Medicine, Moscow;

关键词: atherosclerosis;    inflammation;    dyslipidaemia;    pro-inflammatory cytokines;    polyprenol phosphates;    phytosterols;   

DOI  :  10.15829/1728-8800-2013-3-63-67

来源: DOAJ

【 摘 要 】

Hypercholesterolemia (HCH) and vascular inflammation are the main therapeutic targets in atherosclerosis. The paper discusses the results of the studies which have focussed on the effects of a new class of physiologically active substances (polyprenols and β-sitosterols) on lipid profile and pro-inflammatory cytokines in HCH patients with low to moderate cardiovascular risk. Polyprenol phosphates and phytosterols could help to achieve significant changes in lipid profile and normalisation of immunologic parameters.

【 授权许可】

Unknown