Different forms of ghrelin exhibit distinct biological roles in tilapia

Frontiers in Endocrinology

Larry eRiley¹ 

[1] California State University, Fresno;

关键词: Appetite;    Ghrelin;    Homeostasis;    Metabolism;    Tilapia;    GHSR;   

DOI  :  10.3389/fendo.2013.00118

来源: DOAJ

【 摘 要 】

Ghrelin has been identified in all vertebrate classes, including sharks. Each species possesses multiple forms of ghrelin that vary in peptide length and acyl modifications (e.g. n-hexanoic, n- nonanoic, n-octanoic, and n-decanoic acids) including des-acyl ghrelin. Octanolyated ghrelin has been shown to be a potent GH secretagogue, orexigenic factor, and plays a role in overall metabolism in vertebrates.In the tilapia model, octanoylated ghrelin (ghrelin-C8) and decanoylated ghrelin (ghrelin-C10) exhibit different biological actions. This mini review highlights the current knowledge of the differential actions of ghrelin-C8 and ghrelin-C10 from studies in the tilapia model.These findings suggest that the multiple forms of ghrelin may exhibit distinct yet complimentary actions directed towards maintaining overall energy balance in other vertebrates.

【 授权许可】

Unknown