Role of the Bone Microenvironment in the Development of Painful Complications of Skeletal Metastases

Cancers

D.Brooke Widner¹  MatthewR. Eber¹  Yusuke Shiozawa¹  SunH. Park¹ 

[1] Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA;

关键词: cancer-induced bone pain;    bone marrow microenvironment;    osteoclasts;    osteoblasts;    macrophages;    mast cells;    stromal cells;   

DOI  :  10.3390/cancers10050141

来源: DOAJ

【 摘 要 】

Cancer-induced bone pain (CIBP) is the most common and painful complication in patients with bone metastases. It causes a significant reduction in patient quality of life. Available analgesic treatments for CIBP, such as opioids that target the central nervous system, come with severe side effects as well as the risk of abuse and addiction. Therefore, alternative treatments for CIBP are desperately needed. Although the exact mechanisms of CIBP have not been fully elucidated, recent studies using preclinical models have demonstrated the role of the bone marrow microenvironment (e.g., osteoclasts, osteoblasts, macrophages, mast cells, mesenchymal stem cells, and fibroblasts) in CIBP development. Several clinical trials have been performed based on these findings. CIBP is a complex and challenging condition that currently has no standard effective treatments other than opioids. Further studies are clearly warranted to better understand this painful condition and develop more effective and safer targeted therapies.

【 授权许可】

Unknown