Transformation of a microprolactinoma into a mixed growth hormone and prolactin-secreting pituitary adenoma

Frontiers in Endocrinology

CEDRIC eDESSIMOZ¹  SHAHAN eMOMJIAN²  PHILIPPE eMAEDER³  FRANCOIS P. PRALONG³  BENOIT eLHERMITTE³  NELLY ePITTELOUD³  PATRICK eBROWAEYS³ 

[1] Central Institute of the Valais Hospitals;Geneva University Hospitals;Lausanne University Hospital;

关键词: Amenorrhea;    Galactorrhea;    Growth Hormone;    IGF-1;    microprolactinoma;    somatostatin analog;   

DOI  :  10.3389/fendo.2011.00116

来源: DOAJ

【 摘 要 】

Combined prolactin (PRL) and growth hormone (GH) secretion by a single pituitary tumor can occur in approximately 5% of cases. However, in all previously reported patients, combined secretion of both hormones was present at the time of diagnosis. Here we describe a patient initially diagnosed with a pure prolactin-secreting microadenoma, who experienced the progressive apparition of symptomatic autonomous GH secretion while on intermittent long term dopamine agonist therapy. She was operated on, and immunohistochemical analysis of tumour tissue confirmed the diagnosis of pituitary adenoma with uniform co-staining of all cells for both GH and PRL. This patient represents the first documented occurrence of asynchronous development of combined GH and PRL secretion in a pituitary adenoma. Although pathogenic mechanisms implicated remain largely speculative, it emphasizes the need for long term hormonal follow up of patients harboring prolactinomas.

【 授权许可】

Unknown