A Common Variant in the SETD7 Gene Predicts Serum Lycopene Concentrations

Nutrients

Christopher R. D’Adamo¹  Patrick F. McArdle²  Alan R. Shuldiner²  Kathleen A. Ryan²  Laura M. Yerges-Armstrong²  Braxton D. Mitchell²  Nanette I. Steinle²  Antonietta D’Urso³  Richard D. Semba⁴ 

[1] Department of Family & Community Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA;Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA;The Commonwealth Medical College, Scranton, PA 18509, USA;Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA;

关键词: lycopene;    carotenoids;    genome-wide association study (GWAS);    SETD7;    SCARB1;    Old Order Amish;    prostate cancer;   

DOI  :  10.3390/nu8020082

来源: DOAJ

【 摘 要 】

Dietary intake and higher serum concentrations of lycopene have been associated with lower incidence of prostate cancer and other chronic diseases. Identifying determinants of serum lycopene concentrations may thus have important public health implications. Prior studies have suggested that serum lycopene concentrations are under partial genetic control. The goal of this research was to identify genetic predictors of serum lycopene concentrations using the genome-wide association study (GWAS) approach among a sample of 441 Old Order Amish adults that consumed a controlled diet. Linear regression models were utilized to evaluate associations between genetic variants and serum concentrations of lycopene. Variant rs7680948 on chromosome 4, located in the intron region of the SETD7 gene, was significantly associated with serum lycopene concentrations (p = 3.41 × 10−9). Our findings also provided nominal support for the association previously noted between SCARB1 and serum lycopene concentrations, although with a different SNP (rs11057841) in the region. This study identified a novel locus associated with serum lycopene concentrations and our results raise a number of intriguing possibilities regarding the nature of the relationship between SETD7 and lycopene, both of which have been independently associated with prostate cancer. Further investigation into this relationship might help provide greater mechanistic understanding of these associations.

【 授权许可】

Unknown