BMC Medical Research Methodology | |
Melanocortin |
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关键词: Genetic epidemiology; Melanoma; Meta-analysis; Pooled-analysis; Skin cancer; Study design; | |
DOI : 10.1186/1471-2288-12-116 | |
来源: DOAJ |
【 摘 要 】
Abstract
Background
For complex diseases like cancer, pooled-analysis of individual data represents a powerful tool to investigate the joint contribution of genetic, phenotypic and environmental factors to the development of a disease. Pooled-analysis of epidemiological studies has many advantages over meta-analysis, and preliminary results may be obtained faster and with lower costs than with prospective consortia.
Design and methods
Based on our experience with the study design of the Melanocortin-1 receptor (
Discussion
Methodological guidelines to correctly design and conduct pooled-analyses are needed to facilitate application of such methods, thus providing a better summary of the actual findings on specific fields.
【 授权许可】
Unknown