Wnt Signaling in the Breast: From Development to Disease

Frontiers in Cell and Developmental Biology

Alejandra Bruna¹  Willy Antoni Abreu de Oliveira²  Frederic Lluis²  Youssef El Laithy²  Daniela Annibali⁴ 

[1] Centre for Paediatric Oncology Experimental Medicine, Centre for Cancer Evolution, Molecular Pathology Division, London, United Kingdom;Department of Development and Regeneration, Stem Cell Institute, Katholieke Universiteit (KU) Leuven, Leuven, Belgium;Department of Oncology, Gynecological Oncology Laboratory, Leuven Cancer Institute (LKI), KU Leuven, Leuven, Belgium;Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, Netherlands;

关键词: Wnt;    breast;    development;    cancer;    signaling;   

DOI  :  10.3389/fcell.2022.884467

来源: DOAJ

【 摘 要 】

The Wnt cascade is a primordial developmental signaling pathway that plays a myriad of essential functions throughout development and adult homeostasis in virtually all animal species. Aberrant Wnt activity is implicated in embryonic and tissue morphogenesis defects, and several diseases, most notably cancer. The role of Wnt signaling in mammary gland development and breast cancer initiation, maintenance, and progression is far from being completely understood and is rather shrouded in controversy. In this review, we dissect the fundamental role of Wnt signaling in mammary gland development and adult homeostasis and explore how defects in its tightly regulated and intricated molecular network are interlinked with cancer, with a focus on the breast.

【 授权许可】

Unknown