Oligodendroglial Epigenetics, from Lineage Specification to Activity-Dependent Myelination

Life

Mathilde Pruvost¹  Sarah Moyon¹ 

[1] Neuroscience Initiative Advanced Science Research Center, CUNY, 85 St Nicholas Terrace, New York, NY 10031, USA;

关键词: oligodendrocyte;    oligodendrocyte progenitor cell;    epigenetics;    DNA methylation;    histone;    chromatin;   

DOI  :  10.3390/life11010062

来源: DOAJ

【 摘 要 】

Oligodendroglial cells are the myelinating cells of the central nervous system. While myelination is crucial to axonal activity and conduction, oligodendrocyte progenitor cells and oligodendrocytes have also been shown to be essential for neuronal support and metabolism. Thus, a tight regulation of oligodendroglial cell specification, proliferation, and myelination is required for correct neuronal connectivity and function. Here, we review the role of epigenetic modifications in oligodendroglial lineage cells. First, we briefly describe the epigenetic modalities of gene regulation, which are known to have a role in oligodendroglial cells. We then address how epigenetic enzymes and/or marks have been associated with oligodendrocyte progenitor specification, survival and proliferation, differentiation, and finally, myelination. We finally mention how environmental cues, in particular, neuronal signals, are translated into epigenetic modifications, which can directly influence oligodendroglial biology.

【 授权许可】

Unknown