Protective effect of curcumin on busulfan-induced renal toxicity in male rats

Renal Failure

Vahid Ebrahimi¹  Mohammad-Amin Abdollahifar²  Amirreza Khosravi²  Amirhosein Hasani²  Abbas Aliaghaei²  Amir Raoofi³  Ali Mehdizadeh⁴  Mohammad Asadi⁴ 

[1] Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences;Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences;Leishmaniasis Research Center, Department of Anatomy, Sabzevar University of Medical Sciences;Student Research Committee, Department and Faculty of Medical Sciences, Shahid Beheshti University of Medical Sciences;

关键词: busulfan;    curcumin;    male rats;    renal toxicity;   

DOI  :  10.1080/0886022X.2020.1818580

来源: DOAJ

【 摘 要 】

Aim The aim of this study was to evaluate the effects of curcumin in an experimental model of busulfan-induced renal toxicity with emphasis on importance of histological alterations. Methods In this study, we utilized 32 adult male Wistar rats (250 ± 10 g). All the animals were divided into four experimental groups randomly: (I) Control; (II) Busulfan (40 mg/kg); (III) Olive oil; and (IV) Curcumin (80 mg/kg/day). Finally, the rats were euthanized and kidney tissues were taken for histopathology experiments, serum BUN, and creatinine level, reactive oxygen species (ROS) production and glutathione disulfide (GSH) activity. Results Our result showed that the reduction in body weight and kidney weight in busulfan groups in comparison with the control and curcumin groups. The result in this study also showed that the reduction in BUN, creatinine, and ROS production in curcumin groups in comparison with the busulfan group together with an increasing of GSH activity compared to busulfan induced rats. Conclusion Our results of this study indicated that that the reduction in body weight, kidney weight, total volume of kidney, total length of nephron tubules, and numerical density of glomeruli and nephron tubules in busulfan groups in comparison with the control and curcumin groups However, curcumin can be an alternative choice for therapeutically and research purposes in the disturbing kidney after treatment with busulfan.

【 授权许可】

Unknown