Glycated hemoglobin in camel: Minimal correlation with blood glucose level

Archives of Biological Sciences

关键词: blood;    camel;    glucose;    glycation;    hemoglobin;    modeling;   

DOI  :  10.2298/ABS1303911B

来源: DOAJ

【 摘 要 】

Glucose and glycated hemoglobin (Hb) in the blood of camel (Camelusdromedarius) and cow (Bos taurus) were analyzed and compared with humanvalues. Camel displayed high blood glucose concentration (9.7±2.8 mM) but alow level of glycated-Hb (3.4± 0.23%).Cow blood samples did not showsufficient variations in glucose concentrations (5.7±0.73 mM) or glycated Hblevels (3.2± 0.11%) compared to human values. The low glycation of camel Hbat higher glucose concentrations suggest that certain factors protect the Hbfrom glycation at high glucose concentrations. Camel Hb also exhibited ahigher electrophoretic mobility than normal hemoglobin of human or cow. CamelHb migrated at a rate corresponding to that of human Hb-C. Bioinformaticstools were used to explore the biochemical basis for the difference in camelHb migratory position and its apparent resistance to glycation.

【 授权许可】

Unknown