Developments in Treatment Methodologies Using Dendrimers for Infectious Diseases

Molecules

Farzana Parveen¹  Nina Filipczak¹  Xiang Li¹  Vladimir Torchilin¹  SatyaSiva Kishan Yalamarty¹ 

[1] Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA;

关键词: dendrimers;    drug delivery;    nanoparticles;    antimicrobial therapy;    antiviral therapy;    infectious diseases;   

DOI  :  10.3390/molecules26113304

来源: DOAJ

【 摘 要 】

Dendrimers comprise a specific group of macromolecules, which combine structural properties of both single molecules and long expanded polymers. The three-dimensional form of dendrimers and the extensive possibilities for use of additional substrates for their construction creates a multivalent potential and a wide possibility for medical, diagnostic and environmental purposes. Depending on their composition and structure, dendrimers have been of interest in many fields of science, ranging from chemistry, biotechnology to biochemical applications. These compounds have found wide application from the production of catalysts for their use as antibacterial, antifungal and antiviral agents. Of particular interest are peptide dendrimers as a medium for transport of therapeutic substances: synthetic vaccines against parasites, bacteria and viruses, contrast agents used in MRI, antibodies and genetic material. This review focuses on the description of the current classes of dendrimers, the methodology for their synthesis and briefly drawbacks of their properties and their use as potential therapies against infectious diseases.

【 授权许可】

Unknown