In Vitro Antimicrobial, Antioxidant and Anticancer Activities of Egyptian Citrus Beebread

Molecules

AmmarB. Altemimi¹  HatemSharaf El-Din²  TarekGamal Abedelmaksoud³  Nesren Elsayed³  Anubhav Pratap-Singh⁴  HanaaY. Ahmed⁵ 

[1] Department of Food Science, College of Agriculture, University of Al-Basrah, Basrah 61004, Iraq;Economic Entomology and Pesticides Department, Faculty of Agriculture, Cairo University, Giza 12613, Egypt;Food Science Department, Faculty of Agriculture, Cairo University, Giza 12613, Egypt;Food, Nutrition & Health Program, Faculty of Land and Food Systems, The University of British Columbia, Vancouver, BC V6T 1Z4, Canada;The Regional Center for Mycology and Biotechnology, Al-Azhar University, Cairo 11651, Egypt;

关键词: honeybee;    minerals;    free sugar;    fatty acid;    bioactive compounds;   

DOI  :  10.3390/molecules26092433

来源: DOAJ

【 摘 要 】

In this study, Egyptian beebread (EBB) was investigated for its nutritive value, chemical composition, antioxidant properties, antimicrobial and antitumor activities. Results indicated that EBB was a good source of protein (23.58 ± 0.183 g/100 g BB), total free sugar (20.266 ± 0.930) and potassium (290.202 ± 2.645 mg/100 g). Additionally, 14 fatty acids were identified in EBB, wherein polyunsaturated and monounsaturated fatty acids represented 51.06% ± 0.09% and 9.86% ± 0.01%, respectively. The EBB extract exhibited almost 400% better antiradical activity than BHT, with IC₅₀ of EBB extract being 10.7 µg/mL compared to 39.5 µg/mL for BHT. EBB exhibited higher inhibitory activity than the reference compound against Staphylococcus aureus and Escherichia coli, followed by Bacillus subtilis. No inhibitory activity was observed against Aspergillus Niger. Additionally, the highest inhibitory activity was recorded against Caco-2 cells, followed by PC3 and HepG-2 cancer cell lines with IC₅₀ values 262, 314 and 386 μg/mL, respectively. These findings establish the potential of EBB as an antioxidant, antimicrobial and antitumor agent, with possible applications as natural food supplements and natural preservatives.

【 授权许可】

Unknown