‘Model T’ cells: a time-tested vehicle for gene therapy

Frontiers in Immunology

Sid P Kerkar¹ 

[1] National Cancer Institute, National Institutes of Health;

关键词: Adenoviruses, Human;    Autoimmune Diseases;    Chemokines;    Costimulatory and Inhibitory T-Cell Receptors;    Cytokines;    Dendritic Cells;   

DOI  :  10.3389/fimmu.2013.00304

来源: DOAJ

【 摘 要 】

T lymphocytes first carried foreign genes safely into humans over two decades ago. Since these pioneering studies, scientific techniques to better understand the genomic landscape of cells has directly led to a more sophisticated appreciation of the diversity, functional complexity, and therapeutic potential of T cells. Through the use of mouse models, we now know the function of the many genes that are critical for T cells to recognize foreign, mutated, or self-antigens and the factors responsible for the lineage diversification of T cells that lead to inhibitory or stimulatory immune responses. This knowledge combined with well-established modalities to introduce genes into T cells allows for the design of effector and memory CD8 and CD4T lymphocytes specific for viral, fungal, bacterial, parasitic and tumor antigens and to design regulatory lymphocytes specific for the self-antigens responsible for autoimmune and inflammatory diseases. Here, I review strategies for designing the ideal T cell by introducing genes controlling 1) the secretion of cytokines/chemokines and their receptors, 2) T cell receptor specificity, 3) chimeric-antigen receptors that enable for the recognition of surface antigens in an MHC-independent fashion, 4) co-stimulatory/inhibitory surface molecules, and 5) disease defining single-gene factors.

【 授权许可】

Unknown