Early-life environmental exposure determinants of child behavior in Europe: A longitudinal, population-based study

Environment International

Xavier Basagaña¹  Regina Gražulevičienė¹  Monica López-Vicente¹  Kristine B. Gützkow¹  Sandra Marquez¹  John Wright¹  Cathrine Thomsen¹  Leda Chatzi¹  Charline Warembourg²  Rosie McEachan³  Line Smastuen Haug⁴  Claire Philippat⁵  Remy Slama⁶  Juan R. Gonzalez⁶  Marina Vafeidi⁶  Sandra Andrusaityte⁶  Montserrat de Castro⁶  Dan Manson⁶  Jordi Julvez⁶  Carles Hernandez-Ferrer⁷  Barbara Heude⁸  Martine Vrijheid⁹  Jose Urquiza⁹  Jorunn Evandt⁹  Mariza Kampouri⁹  Oliver Robinson⁹  Léa Maitre⁹  Monica Guxens⁹  Maribel Casas⁹  Ibon Tamayo-Uria^1,10  Mark Nieuwenhuijsen^1,11 

[1] CIBER Epidemiologa y Salud Pública (CIBERESP), Madrid, Spain;Corresponding author at: ISGlobal, Barcelona Biomedical Research Park (PRBB), Barcelona, Spain.;Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre-Sophia Children's Hospital, PO Box 2060, 3000 CB Rotterdam, the Netherlands;Division of Immunology and Immunotherapy, Cima Universidad de Navarra and “Instituto de Investigación Sanitaria de Navarra (IdISNA)”, Pamplona, Spain;ISGlobal, Barcelona, Spain;Universitat Pompeu Fabra (UPF), Barcelona, Spain;Department of Environment and Health, Norwegian Institute of Public Health, Oslo, Norway;INSERM, Univ. Grenoble Alpes, CNRS, IAB (Institute of Advanced Biosciences), Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Grenoble, France;ISGlobal, Barcelona, Spain;Institut d'Investigació Sanitària Pere Virgili (IISPV), Hospital Universitari Sant Joan de Reus, Reus, Spain;Vytauto Didziojo Universitetas (VDU), Kaunas, Lithuania;

关键词: Exposome;    ADHD;    Behavioural problems;    CBCL;    Chemicals;    Children;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: Environmental exposures in early life influence the development of behavioral outcomes in children, but research has not considered multiple exposures. We therefore aimed to investigate the impact of a broad spectrum of pre- and postnatal environmental exposures on child behavior. Methods and findings: We used data from the HELIX (Human Early Life Exposome) project, which was based on six longitudinal population-based birth cohorts in Europe. At 6–11 years, children underwent a follow-up to characterize their exposures and assess behavioral problems. We measured 88 prenatal and 123 childhood environmental factors, including outdoor, indoor, chemical, lifestyle and social exposures. Parent-reported behavioral problems included (1) internalizing, (2) externalizing scores, using the child behavior checklist (CBCL), and (3) the Conner’s Attention Deficit Hyperactivity Disorder (ADHD) index, all outcomes being discrete raw counts. We applied LASSO penalized negative binomial regression models to identify which exposures were associated with the outcomes, while adjusting for co-exposures. In the 1287 children (mean age 8.0 years), 7.3% had a neuropsychiatric medical diagnosis according to parent’s reports. During pregnancy, smoking and car traffic showing the strongest associations (e.g. smoking with ADHD index, aMR:1.31 [1.09; 1.59]) among the 13 exposures selected by LASSO, for at least one of the outcomes. During childhood, longer sleep duration, healthy diet and higher family social capital were associated with reduced scores whereas higher exposure to lead, copper, indoor air pollution, unhealthy diet were associated with increased scores. Unexpected decreases in behavioral scores were found with polychlorinated biphenyls (PCBs) and organophosphate (OP) pesticides. Conclusions: Our systematic exposome approach identified several environmental contaminants and healthy lifestyle habits that may influence behavioral problems in children. Modifying environmental exposures early in life may limit lifetime mental health risk.

【 授权许可】

Unknown