Obesity is associated with severe disease and mortality in patients with coronavirus disease 2019 (COVID-19): a meta-analysis

BMC Public Health

Zixin Cai¹  Jingjing Zhang¹  Yan Yang¹ 

[1] National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University;

关键词: Obesity;    COVID-19;    Predict;    Severity;    Mortality;   

DOI  :  10.1186/s12889-021-11546-6

来源: DOAJ

【 摘 要 】

Abstract Background The coronavirus disease 2019 (COVID-19) pandemic has led to global research to predict those who are at greatest risk of developing severe disease and mortality. The aim of this meta-analysis was to determine the associations between obesity and the severity of and mortality due to COVID-19. Methods We searched the PubMed, EMBASE, Cochrane Library and Web of Science databases for studies evaluating the associations of obesity with COVID-19. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using random- or fixed-effects models. Meta-regression analyses were conducted to estimate regression coefficients. Results Forty-six studies involving 625,153 patients were included. Compared with nonobese patients, obese patients had a significantly increased risk of infection. (OR 2.73, 95% CI 1.53–4.87; I 2  = 96.8%), hospitalization (OR 1.72, 95% CI 1.55–1.92; I 2  = 47.4%), clinically severe disease (OR 3.81, 95% CI 1.97–7.35; I 2  = 57.4%), mechanical ventilation (OR 1.66, 95% CI 1.42–1.94; I 2  = 41.3%), intensive care unit (ICU) admission (OR 2.25, 95% CI 1.55–3.27; I 2  = 71.5%), and mortality (OR 1.61, 95% CI 1.29–2.01; I 2  = 83.1%). Conclusion Patients with obesity may have a greater risk of infection, hospitalization, clinically severe disease, mechanical ventilation, ICU admission, and mortality due to COVID-19. Therefore, it is important to increase awareness of these associations with obesity in COVID-19 patients.

【 授权许可】

Unknown