Regulation of Three Virulence Strategies of Mycobacterium tuberculosis: A Success Story

International Journal of Molecular Sciences

Vitor A. P. Martins dos Santos¹  Jesse C. J. van Dam¹  Peter J. Schaap²  Maria Suarez-Diez²  Niels A. Zondervan² 

[1] Research, Stippeneng 4, 6708 WE Wageningen, The Netherlands;;Laboratory of Systems and Synthetic Biology, Wageningen University &

关键词: Mycobacteria;    virulence;    immune modulation;    dormancy;    escape;    phagosome rupture;    divalent metal;    pore;    cAMP;    manganese;    iron;    zinc;    esx;   

DOI  :  10.3390/ijms19020347

来源: DOAJ

【 摘 要 】

Tuberculosis remains one of the deadliest diseases. Emergence of drug-resistant and multidrug-resistant M. tuberculosis strains makes treating tuberculosis increasingly challenging. In order to develop novel intervention strategies, detailed understanding of the molecular mechanisms behind the success of this pathogen is required. Here, we review recent literature to provide a systems level overview of the molecular and cellular components involved in divalent metal homeostasis and their role in regulating the three main virulence strategies of M. tuberculosis: immune modulation, dormancy and phagosomal rupture. We provide a visual and modular overview of these components and their regulation. Our analysis identified a single regulatory cascade for these three virulence strategies that respond to limited availability of divalent metals in the phagosome.

【 授权许可】

Unknown