Exoskeleton for Biofunctionality Protection of Enzymes and Proteins for Intracellular Delivery

Advanced NanoBiomed Research

Saikat Dutta¹ 

[1] Biological & Molecular Science Laboratory, Amity Institute of Click Chemistry Research & Studies Amity University Sector 125 Noida India;

关键词: antitumor therapeutics;    enzyme deliveries;    exoskeletons;    nanoscale encapsulations;    protein deliveries;   

DOI  :  10.1002/anbr.202000010

来源: DOAJ

【 摘 要 】

Driven by the challenges to protect and restore biofunctionality of enzymes and proteins due to fluctuation of temperature, pH, and solvents, desired tolerances against the intracellular microenvironment can be gained via sheltering enzyme and proteins into nanoscale cages of exoskeleton, one of which involves confinement into the pore and channels of metal–organic frameworks (MOFs). While confining biomolecules, such framework exoskeleton and nanoscale cages should drive the enzyme embedding process and induce the formation of the resulting biocomposite suitable for intracellular delivery for therapeutic applications. Translational challenges faced by framework materials such as ZIF‐8 exoskeleton along with few more MOFs for armoring biofunctionality modulation of enzymes and proteins for intracellular delivery efficiency are highlighted. Herein, enzyme embedding patterns, encapsulation of oxidase enzymes, hybrid protein–MOFs, protected protein delivery, and mechanism of biofunctionality protection are discussed. Furthermore, an attempt is made to highlight the scope of exoskeleton biocomposites.

【 授权许可】

Unknown