MicroRNA in Metabolic Re-Programming and Their Role in Tumorigenesis

International Journal of Molecular Sciences

Marco Tomasetti¹  Lory Santarelli¹  Monica Amati¹  Jiri Neuzil² 

[1] Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona 60020, Italy;Mitochondria, Apoptosis and Cancer Research Group, School of Medical Science and Menzies Health Institute Queensland, Griffith University, Southport, QLD 4222, Australia;

关键词: miRNAs;    metabolic reprogramming;    tumorigenesis;    miR-126 and cancer-stroma environment;    miRNA regulating signaling pathways;   

DOI  :  10.3390/ijms17050754

来源: DOAJ

【 摘 要 】

The process of metabolic re-programing is linked to the activation of oncogenes and/or suppression of tumour suppressor genes, which are regulated by microRNAs (miRNAs). The interplay between oncogenic transformation-driven metabolic re-programming and modulation of aberrant miRNAs further established their critical role in the initiation, promotion and progression of cancer by creating a tumorigenesis-prone microenvironment, thus orchestrating processes of evasion to apoptosis, angiogenesis and invasion/migration, as well metastasis. Given the involvement of miRNAs in tumour development and their global deregulation, they may be perceived as biomarkers in cancer of therapeutic relevance.

【 授权许可】

Unknown