Noncanonical NF-κB in Cancer

Biomedicines

Matthew Tegowski¹  Albert Baldwin² 

[1] Curriculum of Genetics and Molecular Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;

关键词: noncanonical NF-κB;    cancer;    cellular signaling;    inflammation;    tumor initiating cells;    NIK;    RelB;    p52;   

DOI  :  10.3390/biomedicines6020066

来源: DOAJ

【 摘 要 】

The NF-κB pathway is a critical regulator of immune responses and is often dysregulated in cancer. Two NF-κB pathways have been described to mediate these responses, the canonical and the noncanonical. While understudied compared to the canonical NF-κB pathway, noncanonical NF-κB and its components have been shown to have effects, usually protumorigenic, in many different cancer types. Here, we review noncanonical NF-κB pathways and discuss its important roles in promoting cancer. We also discuss alternative NF-κB-independent functions of some the components of noncanonical NF-κB signaling. Finally, we discuss important crosstalk between canonical and noncanonical signaling, which blurs the two pathways, indicating that understanding the full picture of NF-κB regulation is critical to deciphering how this broad pathway promotes oncogenesis.

【 授权许可】

Unknown