Expression of the Costimulatory Molecule B7-H4 in the Decidua and Placental Tissues in Patients with Placental Abruption

Biomedicines

Magdalena Maria Dutsch-Wicherek¹  Anna Knafel²  Monika Bączkowska²  Michał Ciebiera²  Mohamed Ali³  Ewa Przytuła⁴  Jan Faryna⁴  Cezary Wojtyła⁵ 

[1] Centre of Postgraduate Medical Education, Department of Psychiatry, 01-809 Warsaw, Poland;Centre of Postgraduate Medical Education, Second Department of Obstetrics and Gynecology, 01-809 Warsaw, Poland;Clinical Pharmacy Department, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt;Department of Pathology, Bielański Hospital, 01-809 Warsaw, Poland;International Prevention Research Institute-Collaborating Centre, Calisia University, 62-800 Kalisz, Poland;

关键词: B7-H4;    pregnancy;    decidua;    placental abruption;    immunology;    cytotoxicity;   

DOI  :  10.3390/biomedicines10040918

来源: DOAJ

【 摘 要 】

B7 homolog 4 protein (B7-H4), a member of the B7 family, is a immunomodulatory membrane protein. The aim of the study was to evaluate the expression of this protein in the decidua and placental tissues in case of placental abruption (PA) compared to cases of retained placental tissue (RPT) and controls. Tissue samples were obtained from 47 patients with PA, 60 patients with RPT, and 41 healthy controls. The samples were stained for B7-H4 expression, analyzed by an expert pathologist, and a semi-quantitative scale was applied. A statistical analysis revealed that the expression of B7-H4 was significantly higher in the decidua in PA samples compared to samples from patients with RPT (p-value < 0.001) and healthy controls (p-value < 0.001). The expression of B7-H4 in the placental chorionic villus was significantly higher in PA samples in relation to samples from healthy controls (p-value < 0.001) but not in relation to RPT samples (p-value = 0.0853). This finding suggests that B7-H4 might play an important role in mechanisms restoring reproductive tract homeostasis. Further research is necessary in regard to the role of B7-H4 in PA.

【 授权许可】

Unknown