Recent Advances in the Application Peptide and Peptoid in Diagnosis Biomarkers of Alzheimer’s Disease in Blood

Frontiers in Molecular Neuroscience

Zihua Wang²  Zhiyuan Hu³  Yuxin Guo⁵ 

[1] CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, China;Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China;School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan, China;School of Nanoscience and Technology, Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China;University of Chinese Academy of Sciences, Beijing, China;

关键词: Alzheimer’s disease;    blood biomarkers;    diagnosis;    peptide;    peptoid;   

DOI  :  10.3389/fnmol.2021.778955

来源: DOAJ

【 摘 要 】

Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases with irreversible damage of the brain and a continuous pathophysiological process. Early detection and accurate diagnosis are essential for the early intervention of AD. Precise detection of blood biomarkers related to AD could provide a shortcut to identifying early-stage patients before symptoms. In recent years, targeting peptides or peptoids have been chosen as recognition elements in nano-sensors or fluorescence detection to increase the targeting specificity, while peptide-based probes were also developed considering their specific advantages. Peptide-based sensors and probes have been developed according to different strategies, such as natural receptors, high-throughput screening, or artificial design for AD detection. This review will briefly summarize the recent developments and trends of AD diagnosis platforms based on peptide and peptoid as recognition elements and provide insights into the application of peptide and peptoid with different sources and characteristics in the diagnosis of AD biomarkers.

【 授权许可】

Unknown